One way that spam hits your inbox is via web email harvesters spidering through web sites looking for "mailto:" links.

Thus you may want to consider hiding all such links with an obscuring mechanism. One such method is available on this site:

http://www.hiveware.com/enkoder_form.php

Is it worth it?

For some sites perhaps yes, but we take the attitude that an awful lot of email addresses for a domain are pretty obvious anyway. e.g. support, webmaster, help etc. So you are going to get the spam pretty much regardless.